Polyp Polyposis
December 23rd, 2005 by 
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Colon Detoxification » Causes & Diagnosis Diseases of the colon
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polyposis (Polyp)
Familial adenomatous polyposis (FAP) is an inherited condition in which numerous polyps to form in the epithelium of the large intestine. While these are benign, they may become malignant, predisposing patients to colorectal cancer. It inherits in an autosomal dominant fashion.
Signs and symptoms:
From the age of 16 onward, patients develop hundreds to thousands of polyps. These may bleed, leading to admixture of blood in the stool. If the blood is not visible, it is still possible for the patient to develop anemia due to gradually developing iron deficiency. If malignancy develops (the median age in FAP patients is about 40), this may present with weight loss, altered bowel habit, or even with metastasis in the liver or elsewhere.
The genetic determinant in familial polyposis may also predispose carriers to other malignancies, e.g. of the duodenum and stomach. Other signs that may point at FAP are pigmented lesions of the retina (”congenital hypertrophy of the retinal pigment”), jaw cysts, sebaceous cysts, and osteomata (benign bone tumors). The combination of polyposis, osteomas, fibromas and sebaceous cysts is termed Gardner syndrome (with or without abnormal scarring).
Diagnosis and treatment:
In patients with a strong family of colorectal cancer and symptoms suggestive of polyposis, colonoscopy is indicated, with biopsy of a number of polyps (especially of those that appear dysplastic).
Blood tests (liver enzymes) and ultrasound of the abdomen are often performed to rule out metastasis to the liver.
Genetic testing provides the ultimate diagnosis in 95%; genetic counseling is usually needed in families where FAP has been diagnosed. Testing may also aid in the diagnosis of borderline cases in families that are otherwise known to have the FAP mutation.
Treatment:
Treatment for FAP will require frequent surveillance colonoscopy investigations; in a number of cases, removal of the colon is necessary to prevent (or cure) development to malignancy.
Various medications are being investigated for slowing malignant degeneration of polyps, most prominently the non-steroidal anti-inflammatory drugs (NSAIDs).
http://en.wikipedia.org/wiki/Colon_(anatomy)
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